Kawasaki Disease Genetic

Is Kawasaki Disease Genetic. Kawasaki disease KD is an acute febrile systemic vasculitis and the cause of KD is not well understood.

Genetic Variation May Explain Asian Susceptibility To Kawasaki Disease

The systematic literature search of PubMed Medline Embase Web of Science and CNKI identified 164 eligible studies.

Kawasaki disease genetic. It is not a disease one is born with or that one is predetermined to develop. Several susceptibility genes eg ITPKC CASP3 CD40 and ORAI and chromosomal regions have been identified through genome-wide association and genome-wide linkage studies to have association wi. Kawasaki disease is a systemic vasculitis of unknown etiology with clinical observations suggesting a substantial genetic contribution to disease susceptibility.

By examining almost 4000 children of Japanese ancestry this genome-wide association study identified 3 genetic variants associated with the disease. Despite the absence of any etiologic factor genetic predisposition in the occurrence of Kawasaki disease is the area under progressive research. Kawasaki disease KD is a complex disorder.

Other children may suffer permanent damage to the coronary arteries. Children with affected siblings have a tenfold higher risk. Inflammatory disease in children due to pathogens May 8 2020 by Debbie Moon Kawasaki disease is in the news these days in reference to kids with COVID-19 infections.

This systematic review and meta-analysis aimed to better elucidate the roles of genetic factors in Kawasaki disease KD and determine the potential genetic biomarkers of KD. It is likely due to multiple interactions between genes and environmental factors. Viruses bacterial conventional as well as superantigens and genetic polymorphisms have been implicated in the etiology of the disease.

Kawasaki disease KD is a complex disorder which affects genetically susceptible infants and children. However certain gene variants seem to. Dendritic cell-specific intercellular adhesion molecule-3 grabbing non-integrin DC-SIGN CD209 in humans was showed to trigger an anti-inflammatory cascade and associated with KD susceptibility.

Kawasaki disease is common in parts of East Asia particularly Japan. Like other autoimmune diseases both genetics and environment appear to play a role in the development of Kawasaki Disease KD. Genetics and Kawasaki Disease.

Children of parents who have had Kawasaki disease have twice the risk of developing the disorder compared to the general population. The systematic literature search of PubMed Medline Embase Web of. Kawasaki disease is one of the leading causes of acquired heart disease in children while its cause remains essentially unknown.

This systematic review and meta-analysis aimed to better elucidate the roles of genetic factors in Kawasaki disease KD and determine the potential genetic biomarkers of KD. This is due to the fact that regardless of the countries of residence people from Japanese ethnicity are more likely to. The etiology of Kawasaki disease which causes inflammation of blood vessels leading to symptoms such as fever and redness of the eyes lips and tongue is a mystery because it shows seasonal variationshinting at an infectious or other environmental causebut is also more prevalent in children of East Asian ancestrysuggesting that there are genetic factors behind it.

Kawasaki disease arises when genetically predisposed children encounter an as yet unidentified infectious agent which may cause only mild illness or no illness at all in children without the genetic predisposition. Several susceptibility genes eg ITPKC CASP3 CD40 and ORAI and chromosomal regions have been identified through genomewide association and genomewide linkage studies to have association with KD. Kawasaki disease KD is a systemic vasculitis with unknown etiology mainly affecting children in Asian countries.

It is an inflammatory condition that can occur in kids when. Kawasaki disease KD is a complex disorder which affects genetically susceptible infants and children. A predisposition to Kawasaki disease appears to be passed through generations in families but the inheritance pattern is unknown.

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